Familial Variant Testing is a targeted genetic test used to determine whether a known genetic mutation, previously identified in a family member (the proband), is present in other relatives. Instead of analyzing entire genes or panels, this test focuses only on the specific variant, making it faster, more affordable, and highly accurate. It’s commonly used for confirming carrier status, assessing inherited risk, and guiding medical decisions for conditions like hereditary cancers or heart diseases. It also helps clarify uncertain variants (VUS) by tracking their presence across family members. However, it won’t detect new or unrelated mutations outside the tested variant.